Functional polymorphisms of xenobiotics metabolizing enzymes—a research topic

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Functional polymorphisms of xenobiotics metabolizing enzymes—a research topic

The human genome harbors an impressive number of genes encoding enzymes that primarily metabolize or transport drugs or other xenobiotics (XMEs). Genetic and functional variation in these genes is tremendous and has complex consequences, depending, for example, on whether enzyme structure or expression is affected, or whether the produced metabolite is pharmacologically or toxicologically activ...

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ژورنال

عنوان ژورنال: Frontiers in Genetics

سال: 2013

ISSN: 1664-8021

DOI: 10.3389/fgene.2013.00079